· Ball-milling parameters such as ball size and milling time were varied to obtain better alloy properties. After compaction and sintering, the obtained alloy samples were subjected to various characterizations, including grain, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy, X-ray diffraction (XRD), microhardness and ...
Ball milling and hot-melt extrusion co-process. Mixture of the drug and polymer in 1: 1 ratio (w/w, 10 g: 10 g) was blended in a XQM-4L vertical planetary ball milling prior to extrusion (Tianchuang Powder Technology Co. Ltd., Changsha, …
· -Fe-Cr phase was investigated using formula Fe80Cr20. Ball milling process and ultrasonic technique is successfully done to develop solid solubility and improve homogenous, respectively. However, the effect of the Cr to Fe powder is not complete investigated using combination of its process. Ball milling is conducted by milling time of 60 hours and ultrasonic …
· different parameters: milling time (2/10 min), pre lubrication mixing time (5/10 min), lubrication time (1/5 min), compression speed (10/30 rpm), temperature (25°C/37°C), stirrer rpm (50/100 rpm) and stirrer alignment (50/100 mm) were used at two different levels to select three most critical parameters which affect the dissolution profile of
· The ball milling route is a convenient, scalable, and economical method for the synthesis of nanoparticles. For the preparation of YM composite, ball milling has been used as a combination with other routes (above-mentioned methods) but not as a single primary method. 28-31 Fabrication of YM composite using commercial powders by using only ball ...
· In this study, the influence of the preparation technique (ball milling, spray drying, and film casting) of a supersaturated amorphous dispersion on the quality of solubility determinations of indomethacin in polyvinylpyrrolidone was investigated by means of statistical analysis. After annealing of the amorphous dispersions above the crystallization temperature for 2 h, the …
The study was a pioneering attempt to assess the influence of the structural polymorphism (forms I, II, III) of benzocaine on its solubility, apparent solubility, and chemical stability, which are vital parameters for preformulation and formulation work. The impact of differences in the solubility o …
· Solubility Study in Ag-Cu Binary System Prepared By Ball Milling Process S. M. M. Shafiei*, E. Salahi, S. A. Tayebi Fard Materials and Energy Research Center (MERC) (*) Corresponding author: [email protected] (Received:18 Mar. 2012 and Accepted: 23 June 2012) Abstract: Solid solutions of Ag-Cu were prepared via ball milling process, for ...
Al2O3-TiO2-graphite nanocomposite can be used as alternative material for coating application. Fine composite coating particles is commonly produced by milling in a high energy ball milling. This study focused on evaluate the effects on the structural, microstructural and physical properties of Al2O3-TiO2-graphite nanocomposite. The alumina, titania and graphite powder …
· Subsequently, appropriate amounts of n-Hexane (AR, CAS:110–54–3) were added and the ball milling process was conducted for 5 h at the rotational speed of 300 rpm using a high energy planetary ball mill (MITR QM-QX-2L). n-Hexane was used to avoid the agglomeration of particles during the milling. 32 After the termination of ball milling, the ...
· solubility of the pure drug and its physical dispersions. Using ball milling technique the physical dispersions of Nimesulide with the polymers, prepared in the ratios of 1:1, 1:3, 1:5 were subjected to size reduction for two different time intervals of 30 min and 90 min,
The solubility of pure Efavirenz in water (5.7 mg/mL) is significantly increased by the milling process (almost doubled in EFV_55 and EFV_56), and further improved (quad- …
Starting from element copper and tungsten powders, a partial solubility of copper into the cubic tungsten lattice as well as of tungsten into the f.c.c. copper lattice is induced by ball-milling.
· Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Poorly water- ... it is done by milling techniques using jet mill, Volume 5, Issue 1, November – December 2010; Article-007 ISSN 0976 – 044X ... Ball milled products: ...
· Vibratory ball mill • Finer powder particles need longer periods for grinding • In this case, vibratory ball mill is better => here high amount of energy is imparted to the particles and milling is accelerated by vibrating the container • This mill contains an electric motor connected to the shaft of the drum by an elastic coupling.
· In milling processes, it is very probable that different crystal faces are formed depending on the raw material and process parameters. 42, 70 These crystal faces can possess various solubility properties. 71-73 Regarding the properties of raw materials, factors like impurities, solvent inclusion, number of mechanical deformations, and crystal ...
· Ball milling is a widely used technique to reduce particle size [14] and has been shown to influence the transition of materials from crystalline to amorphous form [15,16]; to change the performance of a variety of dosage forms by improving their solubility [17], dissolution [18], and
· We previously reported a successful scale-up monoazidation reaction of Ts-β-CD (the reaction scale was 6.5 g, 5 mmol) in a ball-mill (Supporting Information File 1, Table S1, entries 1–4).Considering that the preparation of Ts-β-CD is laborious, its commercial availability is restricted by high costs and limited number of producers, the systematic investigation on the …
· The steel vial of the ball mill had 250 ml capacity. 21.858 g of powders were put into the container and equal number of steel balls of 1 and 2 cm in diameters were added. Different ball sizes improve accident collisions during milling operation, and minimize the surface layers on the balls and also provide maximum impact energy .
· On the Solubility of Phases in Cemented Carbides ... The changas inthe identity and lattice parameters ofthe phases occurring insintered mixtures ofWC-Co-TaC and WC-Co-TiC-TaC, ... in Table I were prepared by ball - milling commercially pure powders for up to 124 hours. The mixtures were
· Following this, mechanochemical parameters such as increasing the milling frequency and changing the milling mode from vibrational to planetary ball milling were investigated (PAA-11–PAA-13). Choosing a higher milling frequency has a slightly adverse effect on yield, decreasing it from 93 to 82 %.
The solubility of a drug is intrinsically related to the particle size. Reduction of particle size of a drug by various means such as jet mill, rotor stator colloidal mill, ball mill, etc. leads to increase in surface area with enhanced dissolution.
· Besides the mill geometries there exist several easy to control and reasonably well-understood parameters unique to mechanochemical reactions. As mentioned above, the rotational speed (planetary ball mill) or milling frequency (vibrational ball mill) are an easy to adjust parameter to control the energy input in the milled powder.
· in a ball-mill (Supporting Information File€1, Table S1, entries 1–4). Considering that the preparation of Ts-β-CD is laborious [24,25], its commercial availability is restricted by high costs and limited number of producers, the systematic investigation on the influence of the milling parameters on the reaction
In the first-part, two excipients (HPMC and soluplus) were selected from seven, and the optimal ball-milling parameters of speed and time (18 Hz, 15 min) were determined based on solubility-enhancement and flow-ability criteria.
· The use of ball milling as a micronization technique for enhancing drug solubility is well supported by literature dating as far back as the 1970s. Apart from its comminution function, ball milling also serves as an intensive mixing technique capable of producing co-ground drug-excipient mixtures comprising amorphous drug forms intimately mixed ...
· The effect of milling time and speed on solid solubility of V in Al and grain refinement was studied. High-energy ball milling was used to produce Al-xV (x = 2, 5, and 10 at.%) alloys at milling speeds of 280 and 350 RPM. The ball-milling time was varied from 10 to 100 hours. The ball-milled alloys were consolidated under uniaxial pressure of 3GPa at room temperature. …